ParkinsonCanadaV1, Main, Exploration, bibRecord, 003351

Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease : PET evidence of increased dopamine turnover

Identifieur interne : 003351 ( Main/Exploration ); précédent : 003350; suivant : 003352

Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease : PET evidence of increased dopamine turnover

Auteurs : Raul De La Fuente-Fernandez [Canada] ; Jian-Qiang Lu [Canada] ; Vesna Sossi [Canada] ; Salma Jivan [Canada] ; Michael Schulzer [Canada] ; James E. Holden [États-Unis] ; Chong S. Lee [Canada] ; Thomas J. Ruth [Canada] ; Donald B. Calne [Canada] ; A. Jon Stoessl [Canada]

Source :

Annals of neurology [ 0364-5134 ] ; 2001.

RBID : Pascal:01-0202051

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Dopamine, Raclopride, Tomoscintigraphie, Positon, Toxicité, Trouble motricité, Turnover, Complication, Traitement, Homme, Chimiothérapie, Cardiotonique, Catécholamine, Stimulant dopaminergique, Antagoniste dopamine, Neuroleptique, Psychotrope, Récepteur dopaminergique D2, Lévodopa, Voie orale.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Brain (diagnostic imaging), Brain (metabolism), Cardiotonic agent, Catecholamine, Chemotherapy, Complication, D2 Dopamine receptor, Dopamine, Dopamine (metabolism), Dopamine agonist, Dopamine antagonist, Emission tomography, Female, Follow-Up Studies, Human, Humans, Levodopa, Male, Middle Aged, Motility disorder, Neuroleptic, Oral administration, Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Positron, Psychotropic, Raclopride, Synapses (metabolism), Time Factors, Tomography, Emission-Computed, Toxicity, Treatment, Turnover.
MESH :
- chemical , metabolism : Dopamine.
- diagnostic imaging : Brain, Parkinson Disease.
- drug therapy : Parkinson Disease.
- metabolism : Brain, Synapses.
- physiopathology : Parkinson Disease.
- Female, Follow-Up Studies, Humans, Male, Middle Aged, Time Factors, Tomography, Emission-Computed.

Abstract

Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease. To investigate whether such oscillations in mobility can be attributed to changes in the synaptic levels of dopamine, we studied prospectively patients in the early stages of Parkinson's disease with a follow-up after at least 3 years of levodopa treatment. At baseline, 3 positron emission tomography (PET) scans using [¹¹C]raclopride before and after (1 hour and 4 hours) orally administered levodopa were performed on the same day for each patient. Patients who developed "wearing-off" fluctuations during the follow-up period had a different pattern of levodopa-induced changes in [¹¹C]raclopride binding potential (BP) from that observed in patients who were still stable by the end of the follow-up. Thus, 1 hour post-levodopa the estimated increase in the synaptic level of dopamine was 3 times higher in fluctuators than in stable responders. By contrast, only stable responders maintained increased levels of synaptic dopamine in the PET scan performed after 4 hours. These results indicate that fluctuations in the synaptic concentration of dopamine precede clinically apparent "wearing-off" phenomena. The rapid increase in synaptic levels of dopamine observed in fluctuators suggests that increased dopamine turnover might play a relevant role in levodopa-related motor complications.

Affiliations:

Canada, États-Unis

Le document en format XML

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<front><div type="abstract" xml:lang="en">Motor fluctuations are a major disabling complication in the treatment of Parkinson's disease. To investigate whether such oscillations in mobility can be attributed to changes in the synaptic levels of dopamine, we studied prospectively patients in the early stages of Parkinson's disease with a follow-up after at least 3 years of levodopa treatment. At baseline, 3 positron emission tomography (PET) scans using [<sup>11</sup>
C]raclopride before and after (1 hour and 4 hours) orally administered levodopa were performed on the same day for each patient. Patients who developed "wearing-off" fluctuations during the follow-up period had a different pattern of levodopa-induced changes in [<sup>11</sup>
C]raclopride binding potential (BP) from that observed in patients who were still stable by the end of the follow-up. Thus, 1 hour post-levodopa the estimated increase in the synaptic level of dopamine was 3 times higher in fluctuators than in stable responders. By contrast, only stable responders maintained increased levels of synaptic dopamine in the PET scan performed after 4 hours. These results indicate that fluctuations in the synaptic concentration of dopamine precede clinically apparent "wearing-off" phenomena. The rapid increase in synaptic levels of dopamine observed in fluctuators suggests that increased dopamine turnover might play a relevant role in levodopa-related motor complications.</div>
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<name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name>
<name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name>
<name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name>
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<country name="États-Unis"><noRegion><name sortKey="Holden, James E" sort="Holden, James E" uniqKey="Holden J" first="James E." last="Holden">James E. Holden</name>
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{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:01-0202051
   |texte=   Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease : PET evidence of increased dopamine turnover
}}

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La maladie de Parkinson au Canada (serveur d'exploration)

Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease : PET evidence of increased dopamine turnover

Biochemical variations in the synaptic level of dopamine precede motor fluctuations in Parkinson's disease : PET evidence of increased dopamine turnover

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.